Published: Tue, March 20, 2018
Medical | By Jackie Banks

Male contraceptive pill passes first safety test

Male contraceptive pill passes first safety test

A new birth control pill for men with a hormonal component has shown efficacy and safety in preventing pregnancies when used once daily for a month.

According to a report from the Telegraph, the pill contains a drug known as dimethandrolone undecanoate (DMAU), which differs from other similar drugs before it due to the inclusion of a long-chain fatty acid that allows it to metabolize at a slower pace, meaning it should only be taken once a day instead of twice.

Page explained that previous attempts to drive down testosterone levels to reduce sperm production led to side effects and liver toxicity. Despite these incredibly low levels of testosterone, the men did not have symptoms of low testosterone.

They found that testosterone and the two hormones needed for sperm production were especially suppressed in men who took the highest dosage of DMAU. Five persons in each group received a placebo and 12 to 15 men received the DMAU pills. The drug is being developed by the National Institutes of Health (NIH); the group also funded the study, which has not yet been published in a peer-reviewed journal.

Study participants experienced slight decreases in HDL "good" cholesterol and slight weight gain, but these were not a risk for them.

Trump unveils plan against opioid crisis
Trump has declared that fighting the epidemic is a priority for the administration, but critics say the effort has fallen short. Flake told New Hampshire Republicans that someone needs to stop Trump - and it could be him if no one else steps up.

"These promising results are unprecedented in the development of a prototype male pill", Page said. Unlike other forms of oral testosterone, which classically are cleared from the body quickly, this compound contains a specific long-chain fatty acid that slows this clearance making it a flawless "once-a-day" pill.

Volunteers took the drug or placebo for 28 days once daily with food.

As a result, men are not able to get their partners pregnant. DMAU must be taken with food to be effective, Page noted.

There's a new contraceptive in town (well, not now, but possibly soon) and it aims to put the responsibility of safe sex square in the hands of men. The team is now currently working on developing a second compound to block the other sperm-transporting protein with a goal of bringing a hormone-free, reversible male pill to the general public within ten years.

The study was presented Sunday (March 18) at ENDO 2018, the Endocrine Society's 100th annual meeting in Chicago, and the findings have not yet been published in a peer-reviewed journal. One of the major downsides of this medical innovation - and something which had been an issue before 1960 as well - is that women are often expected to deal with birth control by themselves. The researcher added that studies indicate that men prefer taking an oral contraception rather than an injection or implant.

Like this: